Anthracyclines effect on mitochondrial function and biogenesis in normal blood cells of hodgkin lymphoma patients
Gianmario Sambuceti, Simona Coco, Vanessa Cossu, Sonia Carta, Francesco Lanfranchi, Chiara Ghiggi, Davide Ceresa, Kamila Pana, Monica Colombo, Silvia Marconi, Maddalena Ghelardoni, Serena Losacco, Francesca Vitale, Sabrina Chiesa, Anna Maria Orengo, Matteo Bauckneht, Emanuele Angelucci, Cecilia Mari · 2025
Read Anthracyclines effect on mitochondrial function and biogenesis in normal blood cells of hodgkin lymphoma patients by Gianmario Sambuceti, Simona Coco, Vanessa Cossu, Sonia Carta, Francesco Lanfranchi, Chiara Ghiggi, Davide Ceresa, Kamila Pana, Monica Colombo, Silvia Marconi, Maddalena Ghelardoni, Serena Losacco, Francesca Vitale, Sabrina Chiesa, Anna Maria Orengo, Matteo Bauckneht, Emanuele Angelucci, Cecilia Mari (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12816649.txt.
Description
Gianmario Sambuceti and co-authors track how a cancer drug family harms the power plants of normal blood cells, in a 2025 study. The drugs, anthracyclines, gather inside mitochondria. A vicious cycle has been proposed: DNA damage and stress feed each other until function fails. The team tested that idea in lymphoma patients.
Blood cells were sampled from 23 patients before, during, and after a standard drug regimen. A matched healthy group gave a baseline. The team measured oxygen use and counts of mitochondrial DNA copies. Patients were chosen with good early scan responses. Tracking normal cells shows the collateral cost of a curative therapy, which may guide safer dosing.
Catalog record
| CREATOR | Gianmario Sambuceti, Simona Coco, Vanessa Cossu, Sonia Carta, Francesco Lanfranchi, Chiara Ghiggi, Davide Ceresa, Kamila Pana, Monica Colombo, Silvia Marconi, Maddalena Ghelardoni, Serena Losacco, Francesca Vitale, Sabrina Chiesa, Anna Maria Orengo, Matteo Bauckneht, Emanuele Angelucci, Cecilia Mari |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |