Functional extracellular vesicles enable injectable hydrogels with stable osteogenic properties for minimally invasive bone defect repair
Guangliang Liu, Zhengsong Xie, Xinxing Fu, Mingjun Wu · 2025
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Description
Guangliang Liu, Zhengsong Xie, Xinxing Fu, and Mingjun Wu build a cell-free system to heal bone defects, in this 2025 paper. A growth signal called BMP2 heals bone well, but the high doses needed in the clinic can cause bone to grow in the wrong places. The team packed the signal into tiny cell-made bubbles and set them in an injectable gel.
In dishes, the loaded bubbles pushed stem cells toward bone making, and the gel stayed kind to cells while releasing its cargo over two weeks. Injected into mouse leg bone defects, the system grew new bone. The authors pitch it as a safer, needle-based path to repair.
Catalog record
| CREATOR | Guangliang Liu, Zhengsong Xie, Xinxing Fu, Mingjun Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |