MCP-1/CCR2 axis regulates M2 macrophage polarization and immunosuppression in mycobacterium tuberculosis
Guizeng Zhao, Can Guo, Xiaoyang Li, Lei Tan, Xueyang Chen, Feng Tian, Lili Zhang, Xia Wang, Junwei Cui · 2026
Read MCP-1/CCR2 axis regulates M2 macrophage polarization and immunosuppression in mycobacterium tuberculosis by Guizeng Zhao, Can Guo, Xiaoyang Li, Lei Tan, Xueyang Chen, Feng Tian, Lili Zhang, Xia Wang, Junwei Cui (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12813122.txt.
Description
Guizeng Zhao and co-authors show how a signaling pair helps tuberculosis bacteria tame the immune cells sent to kill them, in a study published in 2025. The pair, a messenger called MCP-1 and its receptor CCR2, draws infection-fighting cells to the lung. In infected mice, the team probed this pathway with blockers and gene silencing.
Blocking the receptor lowered a key bacterial protein in lung tissue and restored a self-cleaning marker, easing damage late in infection. Gene scans showed the pathway switching on immune and cell-death genes that the blocker switched back off. At the cell level, the signal pushed macrophages toward a calm state that shelters the bacteria. The authors name the pathway a drug target.
Catalog record
| CREATOR | Guizeng Zhao, Can Guo, Xiaoyang Li, Lei Tan, Xueyang Chen, Feng Tian, Lili Zhang, Xia Wang, Junwei Cui |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |