Identify GDPD3 as a key regulator of epithelial–mesenchymal transition and prostate adenocarcinoma progression via the LPA/LPAR1/AKT axis: transcriptomic and experimental study
Lin Hao, Xiangqiu Chen, Tao He, Tao Wu, Zhiqiang Wen, Ziliang Ji, Xichun Zheng, Qingyou Zheng, Qingchun Zhou, Chengwu He, Qishan Long, Donglin Sun · 2026
Read Identify GDPD3 as a key regulator of epithelial–mesenchymal transition and prostate adenocarcinoma progression via the LPA/LPAR1/AKT axis: transcriptomic and experimental study by Lin Hao, Xiangqiu Chen, Tao He, Tao Wu, Zhiqiang Wen, Ziliang Ji, Xichun Zheng, Qingyou Zheng, Qingchun Zhou, Chengwu He, Qishan Long, Donglin Sun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12813044.txt.
Description
Lin Hao and co-authors named a gene as a driver of prostate cancer growth in a study whose head dates it to 2025. This prostate tumor type is common and varies a lot from man to man, which makes outlook and tracking hard. Scores based on tissue looks lack facts about genes and the tumor's surroundings.
The team mined single-cell and bulk gene data from public sets to hunt for key genes. One gene, GDPD3, stood out and tied to the shift that lets tumor cells spread. Lab tests backed the link, tracing it through a fat signal path that ends in a growth switch. The gene may serve as a marker and a drug target.
Catalog record
| CREATOR | Lin Hao, Xiangqiu Chen, Tao He, Tao Wu, Zhiqiang Wen, Ziliang Ji, Xichun Zheng, Qingyou Zheng, Qingchun Zhou, Chengwu He, Qishan Long, Donglin Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |