The role of age-related genes in idiopathic pulmonary fibrosis and molecular docking analysis of their drug targets
Wei Zhang, Tingting Xia, Qian Zhang · 2026
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Description
Zhang, Xia, and Zhang hunt for aging linked genes in a scarring lung disease and test drug matches in twenty twenty-five. The disease, idiopathic pulmonary fibrosis, stiffens lungs with scar tissue and has no clear cause. Aging is a prime suspect, as old cells pile up and repair goes wrong. The team merged three gene data sets from patients and controls.
Nineteen aging linked genes stood out from the changed set. Two genes sat at the hub of the gene webs they built. Two known compounds docked well onto those hub genes in computer tests. Checks in a fourth data set and in scarred mouse lungs backed the gene findings. The work links cell aging to lung scarring.
Catalog record
| CREATOR | Wei Zhang, Tingting Xia, Qian Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |