Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel
Yao Liu, Xue Han, Weijie Zhang, Qingguo Pei, Shuyu Xu, Haicheng Wang · 2026
Read Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel by Yao Liu, Xue Han, Weijie Zhang, Qingguo Pei, Shuyu Xu, Haicheng Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12812623.txt.
Description
Yao Liu and co-authors ease face nerve pain with sound waves in a mouse study whose head gives the year as 2025. The pain is trigeminal neuropathic pain, a burning state after nerve harm. Swelling along the nerve drives much of it. Gentle pulsed ultrasound, called LIPUS, is known to calm swelling in other diseases. The team tied off part of a face nerve in mice to mimic the state.
Tied nerves brought lasting swelling and sharp touch pain. Ultrasound care eased both. A channel called Pannexin 1 rose after the tie and helped drive the swelling. Ultrasound held that channel down in nerve, ganglion, and cord tissue. Silencing the channel with a gene tool also eased the touch pain, which pins its role.
Catalog record
| CREATOR | Yao Liu, Xue Han, Weijie Zhang, Qingguo Pei, Shuyu Xu, Haicheng Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |