Case Report: POEMS syndrome secondary to multiple solitary plasmacytomas complicated by hypertriglyceridemia
Wenchao Chen, Fang Xue, Na Wang, Zilong Zhang, Cunshui Xue, Xia Lian · 2026
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Description
Six doctors in China report a hidden cause of POEMS syndrome in a case paper whose text is dated 2025. The syndrome bundles nerve damage, organ swelling, hormone faults, abnormal protein, and skin change, and diagnosis usually leans on finding that protein. This patient, in their early fifties, had none detectable.
Numbness, weakness, darkened skin, leg swelling, thyroid failure, and very high blood triglycerides pointed to a multisystem disease. Repeated blood and marrow tests found no monoclonal protein. Imaging and biopsy of the hip region then revealed several solitary plasmacytomas with lambda restriction, which secured the diagnosis. Bortezomib based chemotherapy brought clear improvement. The case warns against ruling the syndrome out on protein tests alone.
Catalog record
| CREATOR | Wenchao Chen, Fang Xue, Na Wang, Zilong Zhang, Cunshui Xue, Xia Lian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |