Altered cortical-striatal circuits connectivity is associated with psychotic symptoms in patients with first-episode, drug-naïve early-onset schizophrenia
Lu Wang, Ruishan Liu, Juan Liao, Fan Li, Lihua Zhuo, Hongwei Li · 2026
Read Altered cortical-striatal circuits connectivity is associated with psychotic symptoms in patients with first-episode, drug-naïve early-onset schizophrenia by Lu Wang, Ruishan Liu, Juan Liao, Fan Li, Lihua Zhuo, Hongwei Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12812569.txt.
Description
Lu Wang and five co-authors studied brain wiring changes in early-onset schizophrenia, in work the text head dates to 2025. Patients were in their first episode and had never taken medication. Brain scans from twenty-one patients were compared with matched healthy controls. A prior meta-analysis picked the seed regions for their wiring analysis.
Patients showed weaker links between a frontal region and two parts of the cerebellum. A link between a deep brain hub and a rear region was stronger than normal. That stronger link tracked with higher delusion scores. Flow analysis found extra drive from the hub toward an emotion region. One frontal link was dampened instead. Most flow changes did not track symptoms directly. The authors argue the stronger hub link may be a key mechanism behind psychotic symptoms.
Catalog record
| CREATOR | Lu Wang, Ruishan Liu, Juan Liao, Fan Li, Lihua Zhuo, Hongwei Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |