Case Report: Pulmonary enteric adenocarcinoma harboring KRAS/TP53/APC mutations with contralateral lung metastasis: diagnostic challenges and molecular insights
Mengjie Mao, Mengling Hu, Qingxiu Tao, Zhuo Zuo, Bin Liu · 2026
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Description
Mengjie Mao, Mengling Hu, Qingxiu Tao, Zhuo Zuo, and Bin Liu report a rare lung cancer that mimics bowel cancer under the microscope. The head of the text dates the report to 2025, though the catalog lists 2026. Pulmonary enteric adenocarcinoma grows gland structures like colorectal tumors, and here it appeared in both lungs of an elderly man at once, a presentation barely documented before.
Stains for bowel markers came back positive while lung markers were negative, complicating the call between a lung primary and spread from the gut. Gene tests found KRAS, TP53, and APC mutations together, pointing to a bowel-like growth program. Surgery plus chemo and radiation brought short-term stability. The case argues for joint molecular and stain profiling.
Catalog record
| CREATOR | Mengjie Mao, Mengling Hu, Qingxiu Tao, Zhuo Zuo, Bin Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |