Mercury-induced neurotoxicity in rat: in vivo and in silico studies of thymoquinone modulatory effect via oxidative stress and inflammation, HO-1/NRF/Trx/Trx-R trajectories
Solomon Owumi, Moses Otunla, Jesutosin O Babalola, Uche Arunsi, Chioma E Irozuru, Ahmad Altayyar, Olatunde Owoeye · 2025
Read Mercury-induced neurotoxicity in rat: in vivo and in silico studies of thymoquinone modulatory effect via oxidative stress and inflammation, HO-1/NRF/Trx/Trx-R trajectories by Solomon Owumi, Moses Otunla, Jesutosin O Babalola, Uche Arunsi, Chioma E Irozuru, Ahmad Altayyar, Olatunde Owoeye (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12811909.txt.
Description
Seven authors test a plant compound against mercury poisoning of the brain in rats in this 2025 study. Mercury exposure is linked to brain disorders through oxidative stress, inflammation, and cell death, and thymoquinone, from black seed, is known to fight all three.
Groups of rats got mercury alone, the compound alone, or both together at two doses for 28 days. Mercury alone cut movement and exploration and raised anxiety-like behavior. Adding the compound improved behavior and restored antioxidant levels in two brain regions, while cutting stress and inflammation markers. Brain tissue checks and computer modeling backed the protective picture the authors draw.
Catalog record
| CREATOR | Solomon Owumi, Moses Otunla, Jesutosin O Babalola, Uche Arunsi, Chioma E Irozuru, Ahmad Altayyar, Olatunde Owoeye |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |