Efficacy and safety of isatuximab subcutaneous plus carfilzomib and dexamethasone in patients with relapsed/refractory multiple myeloma: results of the Phase 2 study IZALCO
Gurdeep Parmar, Marcelo Capra, Fernanda Seguro, Vania Hungria, Meletios-Athanasios Dimopoulos, Sosana Delimpasi, Jiří Minařík, Ivan Špička, Luděk Pour, Herlander Marques, Graça Esteves, Kazutaka Sunami, Junichiro Yuda, Roman Hájek, Jana Mihályová, Christine Soufflet, Disa Yu, Khadija Benlhassan, Vic · 2025
Read Efficacy and safety of isatuximab subcutaneous plus carfilzomib and dexamethasone in patients with relapsed/refractory multiple myeloma: results of the Phase 2 study IZALCO by Gurdeep Parmar, Marcelo Capra, Fernanda Seguro, Vania Hungria, Meletios-Athanasios Dimopoulos, Sosana Delimpasi, Jiří Minařík, Ivan Špička, Luděk Pour, Herlander Marques, Graça Esteves, Kazutaka Sunami, Junichiro Yuda, Roman Hájek, Jana Mihályová, Christine Soufflet, Disa Yu, Khadija Benlhassan, Vic (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12811394.txt.
Description
Gurdeep Parmar and co-authors report results of the Phase 2 IZALCO study, published in 2025, on a new way to give a myeloma drug under the skin. The drug, isatuximab, was paired with two other drugs for patients whose multiple myeloma had returned or stopped responding. A wearable injector placed on the body was compared with a hand-given injection.
Seventy-four patients took part, most after one prior line of treatment. About eighty percent responded to the treatment, meeting the study's main goal. Three quarters of patients preferred the wearable injector over the hand method. How the drug was given did not change how well it worked, its safety, or its levels in the body. The authors say the injector offers a handy option for patients.
Catalog record
| CREATOR | Gurdeep Parmar, Marcelo Capra, Fernanda Seguro, Vania Hungria, Meletios-Athanasios Dimopoulos, Sosana Delimpasi, Jiří Minařík, Ivan Špička, Luděk Pour, Herlander Marques, Graça Esteves, Kazutaka Sunami, Junichiro Yuda, Roman Hájek, Jana Mihályová, Christine Soufflet, Disa Yu, Khadija Benlhassan, Vic |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |