Epithelial pyroptosis-induced TREM1+ macrophages activate Th17 cells to accelerate oral mucosal inflammation
Qianhui Shang, Ziyuan Wang, Jiakuan Peng, Dan Yang, Weiqi Li, Xiaoyu Huang, Maofeng Qing, Hao Cheng, Jiaxin Liu, Hongxia Dan, Xin Zeng, Yu Zhou, Dunfang Zhang, Hao Xu, Qianming Chen · 2025
Read Epithelial pyroptosis-induced TREM1+ macrophages activate Th17 cells to accelerate oral mucosal inflammation by Qianhui Shang, Ziyuan Wang, Jiakuan Peng, Dan Yang, Weiqi Li, Xiaoyu Huang, Maofeng Qing, Hao Cheng, Jiaxin Liu, Hongxia Dan, Xin Zeng, Yu Zhou, Dunfang Zhang, Hao Xu, Qianming Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12811386.txt.
Description
Shang and a large team trace in twenty twenty-five a chain of cell events that drives long-lasting mouth inflammation in oral lichen planus. The chronic disease varies in look and can turn cancerous, and its drivers were unclear. Using single-cell and spatial gene maps, a big patient cohort, lab tests, and tissue staining, the team followed signals from surface cells to immune cells.
They found surface cells dying by a fiery route switch on a class of macrophages. Those cells release a signal that activates a helper T cell type, speeding tissue inflammation. The team also built a public atlas linking mouth and gut inflammation data. They offer the chain as a drug target and the atlas as a shared tool.
Catalog record
| CREATOR | Qianhui Shang, Ziyuan Wang, Jiakuan Peng, Dan Yang, Weiqi Li, Xiaoyu Huang, Maofeng Qing, Hao Cheng, Jiaxin Liu, Hongxia Dan, Xin Zeng, Yu Zhou, Dunfang Zhang, Hao Xu, Qianming Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |