Establishment of a novel brainstem ischemic dysphagia model: single-cell sequencing reveals the molecular mechanisms underlying mPES intervention
Yueqin Tian, Qianqian Wang, Jiahui Hu, Jia Qiao, Chao Li, Xiangxiang Zhang, Tingting Jiang, Nenggui Xu, Hongmei Wen, Zulin Dou, Qiuping Ye · 2025
Read Establishment of a novel brainstem ischemic dysphagia model: single-cell sequencing reveals the molecular mechanisms underlying mPES intervention by Yueqin Tian, Qianqian Wang, Jiahui Hu, Jia Qiao, Chao Li, Xiangxiang Zhang, Tingting Jiang, Nenggui Xu, Hongmei Wen, Zulin Dou, Qiuping Ye (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12809966.txt.
Description
Yueqin Tian and co-authors build a new rat model of swallowing trouble after brainstem stroke, and test a stimulation therapy in it, in a 2025 paper. Older models of post-stroke dysphagia come from cortical strokes. Brainstem strokes are more likely to cause swallowing problems, and the mechanism differs by where the damage sits. A model based on the brainstem was needed to study the right process.
They induce brainstem ischemia with a light-triggered clotting method, confirmed by MRI and tissue checks. Swallowing is measured with a video X-ray study, alongside behavior tests. After treatment with modified pharyngeal electrical stimulation, swallowing is retested. Single-cell gene sequencing then explores how the therapy works at the molecular level.
Catalog record
| CREATOR | Yueqin Tian, Qianqian Wang, Jiahui Hu, Jia Qiao, Chao Li, Xiangxiang Zhang, Tingting Jiang, Nenggui Xu, Hongmei Wen, Zulin Dou, Qiuping Ye |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |