Persistent pneumococcal colonisation in antiretroviral-treated HIV infection is associated with nasal inflammation
Joseph Aston Phiri, Lusako Lucky Sibale, Gloria Kapira, Lukerensia Mlogoti, James Tchado Nyirenda, Ndaona Mitole, Alice Kusakala, Charles Ndovi, Precious Chigamba, Aaron Pearson Chirambo, Klara Doherty, Robert K. Nyirenda, Thokozani Kayembe, Janet Zambezi, Edwin Lisimba, Memory Nekati Mvula, David V · 2025
Read Persistent pneumococcal colonisation in antiretroviral-treated HIV infection is associated with nasal inflammation by Joseph Aston Phiri, Lusako Lucky Sibale, Gloria Kapira, Lukerensia Mlogoti, James Tchado Nyirenda, Ndaona Mitole, Alice Kusakala, Charles Ndovi, Precious Chigamba, Aaron Pearson Chirambo, Klara Doherty, Robert K. Nyirenda, Thokozani Kayembe, Janet Zambezi, Edwin Lisimba, Memory Nekati Mvula, David V (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12808677.txt.
Description
Phiri and a large team study why a lung germ lingers in the noses of people with HIV on treatment in twenty twenty-five. Drugs can suppress the virus in blood, yet these patients still catch and carry pneumococcus at high rates. The team sampled nose tissue and immune cells from treated patients. They used cell sorting, single cell gene reads, and lab tests of white cells.
Nose lining cells sent strong calls for white cells, which arrived in a worn, aged state. T cells in the nose looked drained and prone to die. Germ load rose with the level of nose swelling, a loop that may feed itself. The team says fixing nose immunity may cut lung infections.
Catalog record
| CREATOR | Joseph Aston Phiri, Lusako Lucky Sibale, Gloria Kapira, Lukerensia Mlogoti, James Tchado Nyirenda, Ndaona Mitole, Alice Kusakala, Charles Ndovi, Precious Chigamba, Aaron Pearson Chirambo, Klara Doherty, Robert K. Nyirenda, Thokozani Kayembe, Janet Zambezi, Edwin Lisimba, Memory Nekati Mvula, David V |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |