The distinct contribution of sternotomy to the systemic inflammatory response during children's heart surgery
Joel David Bierer, Julia Paffile, Roger Stanzel, Mark Henderson, John Sapp, Pantelis Andreou, Jean Sylvia Marshall, David Horne · 2026
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Description
Joel Bierer and co-authors separate two sources of inflammation in children's heart surgery in a 2025 study. Opening the breastbone gives surgeons access, but the cut itself stirs the immune system. The bypass machine stirs it too, through a distinct pathway. The team reanalyzed a trial of 40 children having congenital heart surgery with bypass.
Blood drawn before and after the breastbone cut let them profile the cut's own signal apart from the machine's. Knowing which mediators come from the incision alone may guide gentler surgical technique or timed drug cover. Children's small bodies feel these responses strongly, so splitting the causes is more than an academic exercise.
Catalog record
| CREATOR | Joel David Bierer, Julia Paffile, Roger Stanzel, Mark Henderson, John Sapp, Pantelis Andreou, Jean Sylvia Marshall, David Horne |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |