Decreased scleral Wnt5ahi fibroblasts exacerbate myopia progression by disrupting extracellular matrix homeostasis in mice
He Zhu, Wei Chen, Xuemei Ling, Shiming Jiao, Le Yu, Huihui Liu, Mengyi Ding, Fan Zhang, Yixin Zhou, Yulu Pan, Zhonglou Zhou, Jia Qu, Fei Zhao, Fuxin Zhao, Xiangtian Zhou · 2025
Read Decreased scleral Wnt5ahi fibroblasts exacerbate myopia progression by disrupting extracellular matrix homeostasis in mice by He Zhu, Wei Chen, Xuemei Ling, Shiming Jiao, Le Yu, Huihui Liu, Mengyi Ding, Fan Zhang, Yixin Zhou, Yulu Pan, Zhonglou Zhou, Jia Qu, Fei Zhao, Fuxin Zhao, Xiangtian Zhou (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12808304.txt.
Description
He Zhu and co-authors find a class of eye wall cells whose loss speeds short sight growth in mice, in a study from 2025. Short sight is very common, yet how the eye wall drives it was poorly known.
Single cell scans showed one fibroblast type, rich in a signal called Wnt5a, fell sharply in eyes made short sighted. Blocking that signal in the eye wall raised short sight and thinned a key wall protein and its fibers. A gene named Sparc sat downstream of the signal, and blocking it mimicked the effect. Wall care of fiber balance is the core story.
Catalog record
| CREATOR | He Zhu, Wei Chen, Xuemei Ling, Shiming Jiao, Le Yu, Huihui Liu, Mengyi Ding, Fan Zhang, Yixin Zhou, Yulu Pan, Zhonglou Zhou, Jia Qu, Fei Zhao, Fuxin Zhao, Xiangtian Zhou |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |