HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2
Flavio Alvarez, Florence Larrous, Ariel Mechaly, Benjamin Bardiaux, Quentin Goor, Ahmed Haouz, Blandine Séon-Méniel, Rodolphe Alves de Sousa, Stéphane Bourg, Didier Desmaële, Bruno Figadère, Nicolas Wolff, Hélène Munier-Lehmann, Célia Caillet-Saguy · 2025
Read HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2 by Flavio Alvarez, Florence Larrous, Ariel Mechaly, Benjamin Bardiaux, Quentin Goor, Ahmed Haouz, Blandine Séon-Méniel, Rodolphe Alves de Sousa, Stéphane Bourg, Didier Desmaële, Bruno Figadère, Nicolas Wolff, Hélène Munier-Lehmann, Célia Caillet-Saguy (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12808273.txt.
Description
Alvarez and co-authors hunt in 2025 small molecules that break a handshake between a coronavirus protein and a human scaffold protein. The viral envelope protein's tail grips the host protein, a contact tied to disease. The team first solved the pair's shape by X-ray, finding an unusual swapped dimer grip.
A fluorescence screen of one thousand compounds built for such contacts found thirty six blockers. Safety and dose tests narrowed those to fourteen leads. Docking simulations showed how the leads might sit in the grip. The leads seed a possible antiviral route against the virus.
Catalog record
| CREATOR | Flavio Alvarez, Florence Larrous, Ariel Mechaly, Benjamin Bardiaux, Quentin Goor, Ahmed Haouz, Blandine Séon-Méniel, Rodolphe Alves de Sousa, Stéphane Bourg, Didier Desmaële, Bruno Figadère, Nicolas Wolff, Hélène Munier-Lehmann, Célia Caillet-Saguy |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |