Brucein D suppresses breast cancer proliferation and migration via targeting the FAK/LRG1 signaling pathway
Lin Li, Haoyang Shen, Yu Qiu, Yan Chen, Weizhu Wu · 2025
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Description
Lin Li and co-authors test a plant compound against breast cancer cells in this 2025 study. The compound, Brucein D, comes from the plant Brucea javanica and had shown anti-cancer signs before. The team focused on a protein called FAK, which helps tumors grow and spread and is found at high levels in breast tumors. They asked whether the compound works by blocking that protein.
In lab dishes, the compound slowed cancer cell growth, movement, and blood-vessel-like tube forming. It also wrecked the cells' power packs, raising harmful oxygen species and draining energy. Gene readouts showed the compound turned down the FAK pathway and a linked gene, LRG1. Cell death followed. The authors name the compound a strong FAK blocker worth further development as a drug candidate.
Catalog record
| CREATOR | Lin Li, Haoyang Shen, Yu Qiu, Yan Chen, Weizhu Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |