Growth factor supplementation modulates survival, morphology, and network activity of neurogenin-2 induced human neurons
Adlin Abramian, Aimilia Damaskou, Ruud F Toonen, Matthijs Verhage · 2025
Read Growth factor supplementation modulates survival, morphology, and network activity of neurogenin-2 induced human neurons by Adlin Abramian, Aimilia Damaskou, Ruud F Toonen, Matthijs Verhage (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12808180.txt.
Description
Adlin Abramian and co-authors test which growth factors lab-grown human neurons truly need to thrive. Their 2025 study uses neurons made by switching on one gene, a standard model for brain disease work. Recipes usually throw in four growth factors, with little proof of what each one does.
Each factor was tried alone and in blends, in two culture broths. Two factors alone kept neurons alive and well branched. Working network activity, though, needed a third factor that the others could not replace. One broth matched the other when fed the right blend. The authors give a clear recipe: pair either survival factor with the activity factor. Their map should help labs tune neuron cultures for disease studies and drug screens.
Catalog record
| CREATOR | Adlin Abramian, Aimilia Damaskou, Ruud F Toonen, Matthijs Verhage |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |