Complement-mediated and direct activation of human neutrophils induced by Premolis semirufa caterpillar toxins
Joel J. M. Gabrili, Ângela A. A. Megale, Giselle Pidde, Trent M. Woodruff, Denise V. Tambourgi · 2026
Read Complement-mediated and direct activation of human neutrophils induced by Premolis semirufa caterpillar toxins by Joel J. M. Gabrili, Ângela A. A. Megale, Giselle Pidde, Trent M. Woodruff, Denise V. Tambourgi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12807961.txt.
Description
Gabrili and co-authors examine how hairs of an Amazon caterpillar rouse human white blood cells, in a paper published in 2025. Contact with Premolis semirufa causes pararamosis, a skin and joint disease of rubber workers. The team exposed neutrophils from healthy donors to hair extract, both directly and through treated plasma, with and without drugs that block the complement system.
The extract switched the cells on through two routes: complement fragments made in the plasma, and a direct effect on the cells themselves. Activated cells released enzymes, signals, and web-like traps. The findings explain the fierce local reaction and point to complement blockers as candidate treatments.
Catalog record
| CREATOR | Joel J. M. Gabrili, Ângela A. A. Megale, Giselle Pidde, Trent M. Woodruff, Denise V. Tambourgi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |