S1PR3 Inhibition in alveolar epithelial cells alleviates pulmonary fibrosis by enhancing alveolar barrier function
Mengyao Hao, Guodong Tang, Enjia Zhou, Rong Fu, MingJin Wang, Huimin Jiang, Xiaoguang Chen, Liping Bai, Xiaoxi Lv, Jing Jin · 2025
Read S1PR3 Inhibition in alveolar epithelial cells alleviates pulmonary fibrosis by enhancing alveolar barrier function by Mengyao Hao, Guodong Tang, Enjia Zhou, Rong Fu, MingJin Wang, Huimin Jiang, Xiaoguang Chen, Liping Bai, Xiaoxi Lv, Jing Jin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12805736.txt.
Description
Mengyao Hao and co-authors test whether silencing one receptor can ease pulmonary fibrosis, a disease that scars the lungs and destroys the air sac walls. Attention fell on a receptor called S1PR3, which sits on the cells lining the air sacs and rises after injury. The team asked whether it helps or harms the barrier those cells form.
Gene data from patients and from mice with drug-induced lung scarring both showed the receptor switched on strongly. Mice bred to lack it in their lung lining developed far less scarring, with less inflammation, less collagen buildup, and a tighter barrier. Blocking the receptor with a drug or with gene silencing raised the levels of proteins that seal the gaps between cells. The authors conclude that this receptor weakens the air sac barrier during fibrosis.
Catalog record
| CREATOR | Mengyao Hao, Guodong Tang, Enjia Zhou, Rong Fu, MingJin Wang, Huimin Jiang, Xiaoguang Chen, Liping Bai, Xiaoxi Lv, Jing Jin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |