Pretreatment Circulating Vascular Biomarkers Predict Cancer Therapy–Related Cardiac Dysfunction During HER2+ Breast Cancer Treatment
Dakota Gustafson, Priya Mistry, Crizza Ching, Inbar Nardi-Agmon, Christopher Yu, Chun-Po Steve Fan, Christian Houbois, Eitan Amir, Thomas Marwick, Husam Abdel-Qadir, Chris McIntosh, Paaladinesh Thavendiranathan, Jason E Fish · 2025
Read Pretreatment Circulating Vascular Biomarkers Predict Cancer Therapy–Related Cardiac Dysfunction During HER2+ Breast Cancer Treatment by Dakota Gustafson, Priya Mistry, Crizza Ching, Inbar Nardi-Agmon, Christopher Yu, Chun-Po Steve Fan, Christian Houbois, Eitan Amir, Thomas Marwick, Husam Abdel-Qadir, Chris McIntosh, Paaladinesh Thavendiranathan, Jason E Fish (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12805402.txt.
Description
Dakota Gustafson and eleven co-authors find that blood markers measured before treatment can warn which breast cancer patients will suffer heart damage from therapy. Their 2025 study follows women with HER2-positive breast cancer on a drug pair known to strain the heart. In a discovery group of 136 women, about twenty-seven percent developed therapy-related heart dysfunction within fifteen months, tracked by heart imaging.
Markers of blood vessel activation and inflammation, rather than the standard heart injury markers, separated the future cases. Three proteins stood out as the strongest predictors in a combined model, and troponin and its usual companions showed no difference at all. MicroRNA signatures added signal. The findings held in a second, smaller cohort. The authors argue a pretreatment blood panel could flag high-risk patients for closer watching before the damage is done.
Catalog record
| CREATOR | Dakota Gustafson, Priya Mistry, Crizza Ching, Inbar Nardi-Agmon, Christopher Yu, Chun-Po Steve Fan, Christian Houbois, Eitan Amir, Thomas Marwick, Husam Abdel-Qadir, Chris McIntosh, Paaladinesh Thavendiranathan, Jason E Fish |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |