Molecular basis of XPF-ERCC1 targeting to SLX4-dependent DNA repair pathways
Junjie Feng, Peter R. Martin, Szymon Kowalski, Maxime Lecot, Nora B. Cronin, Teige Matthews-Palmer, Wojciech Niedzwiedz, Basil J. Greber · 2025
Read Molecular basis of XPF-ERCC1 targeting to SLX4-dependent DNA repair pathways by Junjie Feng, Peter R. Martin, Szymon Kowalski, Maxime Lecot, Nora B. Cronin, Teige Matthews-Palmer, Wojciech Niedzwiedz, Basil J. Greber (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12804970.txt.
Description
Junjie Feng and co-authors map how a DNA cutting complex is steered to repair sites in two thousand twenty-five. The cutter, XPF-ERCC1, works in several repair paths and docks with many partners. One partner, SLX4, scaffolds a three-cutter assembly used to fix cross-linked DNA.
Structures show the cutter bound to SLX4 and to a small helper, SLX4IP, with the key grip points named. When those grips were mutated in human cells, the docking broke. Breaking the helper grip made cells sensitive to a common chemo drug. A full structure with DNA at the active site completes the picture of how the three-cutter complex assembles.
Catalog record
| CREATOR | Junjie Feng, Peter R. Martin, Szymon Kowalski, Maxime Lecot, Nora B. Cronin, Teige Matthews-Palmer, Wojciech Niedzwiedz, Basil J. Greber |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 98 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |