Hyaluronic acid–chitosan conjugated PLGA nanoparticles for dual chemo-photothermal therapy of triple-negative breast cancer
Qing Zhang, Tingting Liu, Fulu Qiao, Wang Li, Chuanqiang Hou · 2025
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Description
Qing Zhang and colleagues present a two thousand twenty-five study of dual-therapy nanoparticles against triple-negative breast cancer. This cancer type lacks the usual drug targets, so chemotherapy side effects dominate care. Combining drug and heat in one targeted particle could sharpen treatment.
Particles carried a chemotherapy drug plus a light-activated dye. Coatings of two natural polymers helped the particles enter cancer cells. Acid conditions and light triggered drug release. Treated cells died more through stress-driven pathways. In mice bearing such tumours, the platform shrank disease more effectively than single approaches.
Catalog record
| CREATOR | Qing Zhang, Tingting Liu, Fulu Qiao, Wang Li, Chuanqiang Hou |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |