Circulating MicroRNAs do not provide a diagnostic benefit over tissue biopsy in patients with brain metastases
Michaela Ruckova, Dagmar Al Tukmachi, Marek Vecera, Tereza Deissova, Robin Jugas, Marketa Hermanova, Michal Hendrych, Leos Kren, Pavel Fadrus, Vaclav Vybihal, Hana Valekova, Radim Jancalek, Tomas Kazda, Ondrej Slaby, Martin Smrcka, Jiri Sana · 2025
Read Circulating MicroRNAs do not provide a diagnostic benefit over tissue biopsy in patients with brain metastases by Michaela Ruckova, Dagmar Al Tukmachi, Marek Vecera, Tereza Deissova, Robin Jugas, Marketa Hermanova, Michal Hendrych, Leos Kren, Pavel Fadrus, Vaclav Vybihal, Hana Valekova, Radim Jancalek, Tomas Kazda, Ondrej Slaby, Martin Smrcka, Jiri Sana (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12804809.txt.
Description
Michaela Ruckova and co-authors test in a 2025 study whether tiny RNA bits in blood or spinal fluid can name the source of cancers that have spread to the brain. Naming the source guides treatment, but today it takes a tissue biopsy. The team sequenced these microRNAs in tumor tissue, plasma, and spinal fluid from the same patients.
Tissue profiles sorted most sources well, telling breast, bowel, kidney, and skin spread apart, though lung cases blurred. The fluid profiles, by contrast, carried little naming power. The sober verdict: liquid biopsy does not yet spare these patients the needle.
Catalog record
| CREATOR | Michaela Ruckova, Dagmar Al Tukmachi, Marek Vecera, Tereza Deissova, Robin Jugas, Marketa Hermanova, Michal Hendrych, Leos Kren, Pavel Fadrus, Vaclav Vybihal, Hana Valekova, Radim Jancalek, Tomas Kazda, Ondrej Slaby, Martin Smrcka, Jiri Sana |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |