Concurrent TB and HIV therapies control TB reactivation during co-infection but not chronic immune activation
Riti Sharan, Yi Zou, Bindu Singh, Vinay Shivanna, Edward J. Dick, Shannan Hall-Ursone, Xi Luo, Guanlin Guo, Shabaana A. Khader, Xavier Alvarez, Jyothi Rengarajan, Zhao Lai, Smriti Mehra, Hulin Wu, Deepak Kaushal · 2025
Read Concurrent TB and HIV therapies control TB reactivation during co-infection but not chronic immune activation by Riti Sharan, Yi Zou, Bindu Singh, Vinay Shivanna, Edward J. Dick, Shannan Hall-Ursone, Xi Luo, Guanlin Guo, Shabaana A. Khader, Xavier Alvarez, Jyothi Rengarajan, Zhao Lai, Smriti Mehra, Hulin Wu, Deepak Kaushal (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12804781.txt.
Description
Riti Sharan and co-authors test combined TB and HIV therapy in macaques in work from 2025. HIV greatly raises the risk that latent tuberculosis wakes into active disease, and antiretroviral therapy alone does not fully restore immune control.
Monkeys with latent TB and a simian form of HIV got three months of weekly TB drugs plus daily antiretrovirals. The combined therapy improved clinical and bacterial outcomes over antiretrovirals alone. Yet lung immune cells stayed depleted and activated, and granulomas persisted with high activity. The authors identify targets for added host-directed therapy.
Catalog record
| CREATOR | Riti Sharan, Yi Zou, Bindu Singh, Vinay Shivanna, Edward J. Dick, Shannan Hall-Ursone, Xi Luo, Guanlin Guo, Shabaana A. Khader, Xavier Alvarez, Jyothi Rengarajan, Zhao Lai, Smriti Mehra, Hulin Wu, Deepak Kaushal |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |