Contemporary medical therapy for heart failure across the ejection fraction spectrum: The OPTIPHARM‐HF registry
Riccardo M. Inciardi, Maurizio Volterrani, Gianluigi Savarese, Muthiah Vaduganathan, Chiara Oriecuia, Carlo M. Lombardi, Cristina Gussago, Piergiuseppe Agostoni, Pietro Ameri, Giuseppe Armentaro, Chiara Arzilli, Nadia Aspromonte, Andrea Attanasio, Roberto Badagliacca, Lucia Barbieri, Pier Paolo Bocc · 2025
Read Contemporary medical therapy for heart failure across the ejection fraction spectrum: The OPTIPHARM‐HF registry by Riccardo M. Inciardi, Maurizio Volterrani, Gianluigi Savarese, Muthiah Vaduganathan, Chiara Oriecuia, Carlo M. Lombardi, Cristina Gussago, Piergiuseppe Agostoni, Pietro Ameri, Giuseppe Armentaro, Chiara Arzilli, Nadia Aspromonte, Andrea Attanasio, Roberto Badagliacca, Lucia Barbieri, Pier Paolo Bocc (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12803666.txt.
Description
Riccardo Inciardi and a very large investigator team audit how completely Italian heart failure patients receive modern drug therapy, in this 2025 registry paper. The catalog creator list breaks off mid-name; the head byline runs long. Guidelines prescribe four drug classes for weak-heart failure, yet real-world use lags in both uptake and dose.
The registry enrolled 3,054 patients at thirty-two centers, split by ejection fraction, the heart's pumping share. In the weakest group, ninety percent took beta-blockers, but newer classes lagged and under sixty percent reached half the target dose. Just 47 percent received all four classes at entry; after one specialist visit, that rose to sixty-four percent, with gains in every class. Milder groups improved too, notably in a diabetes-drug class now central to heart care. The authors say the first visit is a powerful lever, and dosing remains the unfinished half.
Catalog record
| CREATOR | Riccardo M. Inciardi, Maurizio Volterrani, Gianluigi Savarese, Muthiah Vaduganathan, Chiara Oriecuia, Carlo M. Lombardi, Cristina Gussago, Piergiuseppe Agostoni, Pietro Ameri, Giuseppe Armentaro, Chiara Arzilli, Nadia Aspromonte, Andrea Attanasio, Roberto Badagliacca, Lucia Barbieri, Pier Paolo Bocc |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |