Efficacy and safety of intravenous mesenchymal stem cells for ischemic stroke patients, a systematic review and meta-analysis
Maged Elsayed Hassanein, Jaber Fayad, Jilan Ali Shabana, Esraa M. AlEdani, Mahmoud Tarek Hefnawy, Hazem S. Ghaith, Ahmed Negida · 2024
Read Efficacy and safety of intravenous mesenchymal stem cells for ischemic stroke patients, a systematic review and meta-analysis by Maged Elsayed Hassanein, Jaber Fayad, Jilan Ali Shabana, Esraa M. AlEdani, Mahmoud Tarek Hefnawy, Hazem S. Ghaith, Ahmed Negida (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12802624.txt.
Description
Maged Hassanein and co-authors pool the small trial literature on stem cells dripped into veins after ischemic stroke. Four randomized studies, ninety-seven patients in all, tested intravenous mesenchymal stem cells against placebo in the acute and subacute window. Outcomes tracked disability, daily-living independence, and neurological scores, plus death and recurrence for safety.
The stem cell groups finished with better modified Rankin scores and clearly higher Barthel Index gains. Neurological scale improvement, though, did not reach superiority. Death and stroke recurrence ran no higher with cells, with risk ratios under one but wide uncertainty. The authors conclude the therapy looks efficacious and acceptably safe in this sliver of evidence, while the tiny patient total begs for bigger trials.
Catalog record
| CREATOR | Maged Elsayed Hassanein, Jaber Fayad, Jilan Ali Shabana, Esraa M. AlEdani, Mahmoud Tarek Hefnawy, Hazem S. Ghaith, Ahmed Negida |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |