Targeting COX-2 to Alleviate Depressive Phenotypes: Etoricoxib’s Antidepressant Effects in Chronic Unpredictable Mild Stress-Exposed Mice
Santhanalakshmi P, Manimekalai K, Sathiyamoorthy P · 2025
Read Targeting COX-2 to Alleviate Depressive Phenotypes: Etoricoxib’s Antidepressant Effects in Chronic Unpredictable Mild Stress-Exposed Mice by Santhanalakshmi P, Manimekalai K, Sathiyamoorthy P (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12802526.txt.
Description
Santhanalakshmi P, Manimekalai K, and Sathiyamoorthy P test a pain drug as an antidepressant in stressed mice. Their 2025 study uses etoricoxib, an anti-inflammatory medicine that blocks the COX-2 enzyme. The model is chronic unpredictable mild stress, forty-two days of varied small stressors that push mice toward depressive behavior. Fifty-four Swiss albino mice took part across several test arms.
Behavior was read with an open-field test, a forced swim test, and a sucrose preference test, the standard trio for animal depression work. Etoricoxib at two doses reversed the stress effects about as well as fluoxetine, the comparison antidepressant. Stressed mice on the drug spent significantly less time immobile and regained interest in sweet water. The results support inflammation as one lever on mood.
Catalog record
| CREATOR | Santhanalakshmi P, Manimekalai K, Sathiyamoorthy P |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 18 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |