Plasma expression levels of microRNA-101 are downregulated in patients with Parkinson’s disease
Tomohiro Omura, Hiroki Nishiguchi, Haruka Kaneda, Yumi Kitahiro, Kotaro Itohara, Kazuhiro Yamamoto, Toshiyasu Sakane, Ikuko Yano · 2025
Read Plasma expression levels of microRNA-101 are downregulated in patients with Parkinson’s disease by Tomohiro Omura, Hiroki Nishiguchi, Haruka Kaneda, Yumi Kitahiro, Kotaro Itohara, Kazuhiro Yamamoto, Toshiyasu Sakane, Ikuko Yano (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12802125.txt.
Description
Tomohiro Omura and co-authors report that a tiny RNA in blood runs low in people with Parkinson disease, in a 2025 study. The RNA, called miR-101, targets a protein that helps cells clear damaged parts from a stressed inner compartment. That clearing system protects nerve cells, and its failure plays a part in the disease, which kills dopamine-making neurons.
Blood levels of the RNA were much lower in patients than in healthy controls. A standard test of sorting power showed the RNA could tell patients from controls fairly well, though it caught only half the patients at the best cut point. The authors suggest the RNA could serve as a low-burden blood marker for the disease, pending larger checks.
Catalog record
| CREATOR | Tomohiro Omura, Hiroki Nishiguchi, Haruka Kaneda, Yumi Kitahiro, Kotaro Itohara, Kazuhiro Yamamoto, Toshiyasu Sakane, Ikuko Yano |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |