Mechanism of Sodium-Glucose Cotransporter-2 Inhibitors for Uricosuria
Eunjin Bae · 2025
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Description
Eunjin Bae reviews how a class of diabetes drugs also lowers uric acid in the blood, a side benefit with heart and kidney implications. SGLT2 inhibitors, which block sugar reabsorption in the kidney, cut serum urate in trials. Humans, lacking the enzyme uricase, handle urate differently from most mammals, so the route matters.
Bae walks through how the kidneys and gut share urate excretion, and how excess urate drives gout, stones, and wider disease risk. The drugs appear to block a kidney exchanger that reclaims urate, letting more escape in urine. The review ties a glucose drug's hidden plumbing to protection beyond blood sugar.
Catalog record
| CREATOR | Eunjin Bae |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |