A composite biomarker score to predict modified Rodnan skin score in systemic sclerosis: insight from autologous stem cell transplantation international scleroderma trial
Stefano Rodolfi, Kristina Clark, Bahja Ahmed Abdi, Elen Roblin, Medha Kanitkar, Voon H Ong, Alexandre E Voskuyl, Jeska K De Vries-Bouwstra, Jacob M van Laar, Christopher P Denton, Julia Spierings · 2025
Read A composite biomarker score to predict modified Rodnan skin score in systemic sclerosis: insight from autologous stem cell transplantation international scleroderma trial by Stefano Rodolfi, Kristina Clark, Bahja Ahmed Abdi, Elen Roblin, Medha Kanitkar, Voon H Ong, Alexandre E Voskuyl, Jeska K De Vries-Bouwstra, Jacob M van Laar, Christopher P Denton, Julia Spierings (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12801594.txt.
Description
Stefano Rodolfi and co-authors present a 2025 study on a blood score that tracks skin thickening in systemic sclerosis. Skin hardening is a core sign of the disease, usually graded by hand with a skin score that depends on the examiner. A recent deep analysis of blood proteins found three that track the score on their own.
The team combined those three proteins into one score and tested it in twenty-one patients from a stem cell transplant trial at two Dutch centers. They checked how the score matches the skin grade at a single visit and how it moves as skin changes over time. Links with the type of immune treatment were also explored. A blood-based gauge could steady trials and care.
Catalog record
| CREATOR | Stefano Rodolfi, Kristina Clark, Bahja Ahmed Abdi, Elen Roblin, Medha Kanitkar, Voon H Ong, Alexandre E Voskuyl, Jeska K De Vries-Bouwstra, Jacob M van Laar, Christopher P Denton, Julia Spierings |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |