Remimazolam alleviates cerebral ischemia–reperfusion injury of rats by inhibiting NF-κB/NLRP3 inflammasome pyroptosis
Tianxiao Liu, Jing Chen, Min Shi, Chunlai Li, Weixin Dai, Cuihua Chen, Yubo Xie · 2025
Read Remimazolam alleviates cerebral ischemia–reperfusion injury of rats by inhibiting NF-κB/NLRP3 inflammasome pyroptosis by Tianxiao Liu, Jing Chen, Min Shi, Chunlai Li, Weixin Dai, Cuihua Chen, Yubo Xie (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12800310.txt.
Description
Tianxiao Liu and co-authors test a sleep drug as a guard for the brain after stroke in a 2025 study of rats. A stroke cuts blood to the brain; when flow returns, swelling and cell death can worsen the harm. A cell alarm system called the inflammasome helps drive that second wave.
The drug, remimazolam, shrank dead brain area and eased movement faults in rats with blocked brain arteries. In dish-grown brain cells starved of oxygen, it kept more cells alive. A fiery form of cell death dropped in both setups. Gene and protein tests showed the drug turned down the alarm path, from its NF-kB switch to the inflammasome parts. The work hints at a new use for a known drug.
Catalog record
| CREATOR | Tianxiao Liu, Jing Chen, Min Shi, Chunlai Li, Weixin Dai, Cuihua Chen, Yubo Xie |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |