ULK1 knockout suppresses pancreatic cancer progression by inhibiting autophagy and enhancing antitumor immunity
Hana Jeong, Jinju Lee, Ji-Yoon Son, JinKyung Lee, Miju Kang, Sunghyeon Cho, Ji Hyeon Kim, Yoon Jeon, Jonghyun Lee, Dongkwan Shin, Hye-Ran Kim, Ho Lee, Heesun Cheong · 2025
Read ULK1 knockout suppresses pancreatic cancer progression by inhibiting autophagy and enhancing antitumor immunity by Hana Jeong, Jinju Lee, Ji-Yoon Son, JinKyung Lee, Miju Kang, Sunghyeon Cho, Ji Hyeon Kim, Yoon Jeon, Jonghyun Lee, Dongkwan Shin, Hye-Ran Kim, Ho Lee, Heesun Cheong (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12800254.txt.
Description
Hana Jeong and co-authors show that knocking out ULK1 slows pancreatic cancer in a 2025 study. ULK1 starts autophagy, the cell self-eating process that can help or hinder tumors by stage and setting.
Mouse models with ULK1 deleted only in the pancreas were bred and tested beside human tissue data. Tumor tissue showed high ULK1 activity marks in high-grade cases. Deletion cut autophagy and slowed cancer cell growth, colony forming, and invasion. Tumors grew later and lighter, and mice lived longer. The immune setting also shifted, with fewer suppressive cells and more killer T cells. Signal drops may explain the immune gain. The gene stands out as a drug target.
Catalog record
| CREATOR | Hana Jeong, Jinju Lee, Ji-Yoon Son, JinKyung Lee, Miju Kang, Sunghyeon Cho, Ji Hyeon Kim, Yoon Jeon, Jonghyun Lee, Dongkwan Shin, Hye-Ran Kim, Ho Lee, Heesun Cheong |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |