Proteomic profiling reveals age-related changes in transporter proteins in the human blood–brain barrier
Xujia Zhou, Mina Azimi, Niklas Handin, Andrew Riselli, Bianca Vora, Eden Chun, Zilong Dang, Eric Huang, Sook Wah Yee, Per Artursson, Kathleen M. Giacomini · 2025
Read Proteomic profiling reveals age-related changes in transporter proteins in the human blood–brain barrier by Xujia Zhou, Mina Azimi, Niklas Handin, Andrew Riselli, Bianca Vora, Eden Chun, Zilong Dang, Eric Huang, Sook Wah Yee, Per Artursson, Kathleen M. Giacomini (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12800244.txt.
Description
Xujia Zhou and co-authors catalogue how transporter proteins in the human blood-brain barrier change with age, in work from 2025. The barrier gates what enters the brain, from nutrients to drugs. Its makeup keeps shifting from birth through old age, which changes drug reach at each life stage.
The team measured over six thousand proteins in tiny brain vessels across ages. Early life brought changes in the barrier's base layer that may alter its leakiness. Transporters for nutrients and for drug handling shifted with age as well. The maps feed computer models that forecast drug spread into the brain. Such models can guide dosing for children and older adults.
Catalog record
| CREATOR | Xujia Zhou, Mina Azimi, Niklas Handin, Andrew Riselli, Bianca Vora, Eden Chun, Zilong Dang, Eric Huang, Sook Wah Yee, Per Artursson, Kathleen M. Giacomini |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |