Divergent transcriptional regulation of redox-homeostasis and permeability modulate rifampicin tolerance and sensitivity in Mycobacterium tuberculosis
Jees Sebastian, Shuyi Ma, Tige Rustad, Ethan Bustad, Anooja Thomas, Sukhwinder Singh, Pradeep Kumar, David Sherman, David Alland · 2025
Read Divergent transcriptional regulation of redox-homeostasis and permeability modulate rifampicin tolerance and sensitivity in Mycobacterium tuberculosis by Jees Sebastian, Shuyi Ma, Tige Rustad, Ethan Bustad, Anooja Thomas, Sukhwinder Singh, Pradeep Kumar, David Sherman, David Alland (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12800208.txt.
Description
Jees Sebastian and co-authors studied how tuberculosis bacteria become tolerant to a key drug in a 2025 paper. Drug tolerance can slow treatment, while extra sensitivity should speed it. The team screened gene switches in the bacterium, turning each on and watching how the drug response changed under steady drug exposure. Three switches made the bacteria more tolerant when induced. Four others made them extra sensitive.
Two switches gave opposite results through opposite control of two genes that ease chemical stress in the cell. Another switch pushed two genes in opposite directions, yet both changes raised drug entry into the cell, so the result was the same sensitivity. The work shows that tolerance is a network trait, not a single gene trait. Switches that steer the drug response could serve as new drug targets, the authors argue.
Catalog record
| CREATOR | Jees Sebastian, Shuyi Ma, Tige Rustad, Ethan Bustad, Anooja Thomas, Sukhwinder Singh, Pradeep Kumar, David Sherman, David Alland |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |