Phosphorylation of PA28γ by CK2 kinase facilitates HNSCC tumor formation and progression
Silu Sun, Bing Zhong, Ying Wang, Zaiye Li, Yuchen Jiang, Ning Ji, Xiaodong Feng, Rui Liu, Xin Zeng, Xikun Zhou, Chunjie Li, Hang Zhao, Jing Li, Qianming Chen · 2025
Read Phosphorylation of PA28γ by CK2 kinase facilitates HNSCC tumor formation and progression by Silu Sun, Bing Zhong, Ying Wang, Zaiye Li, Yuchen Jiang, Ning Ji, Xiaodong Feng, Rui Liu, Xin Zeng, Xikun Zhou, Chunjie Li, Hang Zhao, Jing Li, Qianming Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12800137.txt.
Description
Silu Sun and co-authors study a protein switch that helps head and neck cancers grow, in a 2025 paper. The protein, PA28gamma, can control many molecules tied to tumor growth. How it is switched on was not well known. The team focused on a chemical mark placed at one site on the protein.
A kinase called CK2 places that mark. The marked form is common across cancers and tied to poor outlook. Mice whose protein could not take the mark resisted induced tumors. Mice with a mark-mimicking form grew tumors faster. The mark also raised levels of a growth-related factor. The chain gives drug makers a clear target in a hard cancer.
Catalog record
| CREATOR | Silu Sun, Bing Zhong, Ying Wang, Zaiye Li, Yuchen Jiang, Ning Ji, Xiaodong Feng, Rui Liu, Xin Zeng, Xikun Zhou, Chunjie Li, Hang Zhao, Jing Li, Qianming Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |