Comprehensive profiling of smoke-induced T cells in mice implicates clonal γδT17 cells as a hallmark of COPD
Xinyue Mei, Junxiang Wang, Yuan Wang, Li Cheng, Xiaoyu Wang, Xinyuan Liu, Ge Bai, Jiaying Zhong, Mingzhu Huang, Suyin Huang, Peiyu Huang, Jieda Cui, Yu Liu, Qianmei Wen, Ruiting Sun, Erkang Yi, Fan Wu, Xiaohui Wu, Ziqing Yuan, Qi Wan, Xiaoyang Zheng, Yujie Zuo, Jingwei Zhang, Leqing Zhu, Yumin Zhou, · 2025
Read Comprehensive profiling of smoke-induced T cells in mice implicates clonal γδT17 cells as a hallmark of COPD by Xinyue Mei, Junxiang Wang, Yuan Wang, Li Cheng, Xiaoyu Wang, Xinyuan Liu, Ge Bai, Jiaying Zhong, Mingzhu Huang, Suyin Huang, Peiyu Huang, Jieda Cui, Yu Liu, Qianmei Wen, Ruiting Sun, Erkang Yi, Fan Wu, Xiaohui Wu, Ziqing Yuan, Qi Wan, Xiaoyang Zheng, Yujie Zuo, Jingwei Zhang, Leqing Zhu, Yumin Zhou, (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12800128.txt.
Description
Smoke-driven lung disease involves immune cells that are still poorly mapped, and a 2025 study by Xinyue Mei and co-authors profiles T cells in smoke-exposed mice. The team used single-cell gene reading, receptor sequencing, and flow checks to trace how these cells change in the airways and blood.
Smoke pulled more T cells into the airways and widened the range of their receptors. One group stood out: gamma delta T cells that make the signal IL-17 and had grown from a few clones. Oddly, these cells protect the lung. Mice lacking them suffered worse smoke damage, while giving the cells back restored protection over time. The authors name this cell group a hallmark of the disease and a possible target.
Catalog record
| CREATOR | Xinyue Mei, Junxiang Wang, Yuan Wang, Li Cheng, Xiaoyu Wang, Xinyuan Liu, Ge Bai, Jiaying Zhong, Mingzhu Huang, Suyin Huang, Peiyu Huang, Jieda Cui, Yu Liu, Qianmei Wen, Ruiting Sun, Erkang Yi, Fan Wu, Xiaohui Wu, Ziqing Yuan, Qi Wan, Xiaoyang Zheng, Yujie Zuo, Jingwei Zhang, Leqing Zhu, Yumin Zhou, |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |