Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Polκ and DNA repair
Yang Jiang, Moritz Przybilla, Linda Bakker, Foster C Jacobs, Dylan Mckeon, Roxanne van der Sluijs, Koichi Sato, Juliëtte Wezenbeek, Joeri van Strien, Jeroen Willems, Alexander E E Verkennis, Jamie Barnett, Adrian Baez Ortega, Federico Abascal, Peter W Villalta, Puck Knipscheer, Inigo Martincorena, S · 2025
Read Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Polκ and DNA repair by Yang Jiang, Moritz Przybilla, Linda Bakker, Foster C Jacobs, Dylan Mckeon, Roxanne van der Sluijs, Koichi Sato, Juliëtte Wezenbeek, Joeri van Strien, Jeroen Willems, Alexander E E Verkennis, Jamie Barnett, Adrian Baez Ortega, Federico Abascal, Peter W Villalta, Puck Knipscheer, Inigo Martincorena, S (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12800090.txt.
Description
Yang Jiang and co-authors trace a source of DNA damage that the body itself makes, and the guards that keep it from causing mutations. A repair path lets cells copy past damaged DNA, but errors can slip in. Their 2025 mouse study focuses on one copying enzyme and on damage to one DNA letter.
Mice lacking that enzyme built up a distinct mutation pattern in liver and kidney. The pattern points to the enzyme copying past guanine damage without errors. A second repair path also clears some of the same damage. Chemical tests found the exact lesions at work, plus new ones handled by the second path. The work shows how repair and tolerance team up to guard tissues.
Catalog record
| CREATOR | Yang Jiang, Moritz Przybilla, Linda Bakker, Foster C Jacobs, Dylan Mckeon, Roxanne van der Sluijs, Koichi Sato, Juliëtte Wezenbeek, Joeri van Strien, Jeroen Willems, Alexander E E Verkennis, Jamie Barnett, Adrian Baez Ortega, Federico Abascal, Peter W Villalta, Puck Knipscheer, Inigo Martincorena, S |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 95 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |