Chromatin accessibility of circulating CD8⁺ T cells differentiates disease severity in IgA nephropathy
Gwanghun Kim, Soojin Lee, Soojin Lee, Suk-Kyung Shin, Sehoon Park, Jung Hun Koh, Semin Cho, Yaerim Kim, Ik Soo Kim, Seung Jae Lee, Chaehwa Seo, Dong-Sup Lee, Hang-Rae Kim, Hyun Mu Shin, Dong Ki Kim, KORNERSTONE investigators · 2025
Read Chromatin accessibility of circulating CD8⁺ T cells differentiates disease severity in IgA nephropathy by Gwanghun Kim, Soojin Lee, Soojin Lee, Suk-Kyung Shin, Sehoon Park, Jung Hun Koh, Semin Cho, Yaerim Kim, Ik Soo Kim, Seung Jae Lee, Chaehwa Seo, Dong-Sup Lee, Hang-Rae Kim, Hyun Mu Shin, Dong Ki Kim, KORNERSTONE investigators (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12800059.txt.
Description
Gwanghun Kim and co-authors read the open-and-shut pattern of DNA in immune cells to grade a kidney disease's severity, in a study published in 2025. IgA nephropathy, a common kidney inflammation, can progress silently, and current markers grade it poorly. The team profiled chromatin access in circulating killer T cells from seventeen biopsy-proven patients split into early and late stages. Hundreds of regions differed between the stages.
Early-stage cells showed more open chromatin and more naive T cells, while late-stage cells carried more worn-out effector cells. Distinct regulatory signatures marked each stage. A weighted score from the top regions separated stages strongly, and lab checks confirmed the patterns. The authors propose blood-based epigenetic markers for early risk sorting. Such tests could personalize monitoring without another biopsy.
Catalog record
| CREATOR | Gwanghun Kim, Soojin Lee, Soojin Lee, Suk-Kyung Shin, Sehoon Park, Jung Hun Koh, Semin Cho, Yaerim Kim, Ik Soo Kim, Seung Jae Lee, Chaehwa Seo, Dong-Sup Lee, Hang-Rae Kim, Hyun Mu Shin, Dong Ki Kim, KORNERSTONE investigators |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |