The role of circulating tumor cell-associated genes in the progression of estrogen receptor-positive breast cancer
Martin Rotbauer, Melanie Dawe, Kevin C. J. Nixon, Julissa Tsao, Tanja Durbic, Monika Sharma, Sheng-Ben Liang, Jie Zhang, Nakita E. K. Gopal, Miralem Mrkonjic, Najd Alshamlan, Adnan Karavelic, Ciara Murray, David W. Cescon, Philippe L. Bedard, Susan J. Done · 2025
Read The role of circulating tumor cell-associated genes in the progression of estrogen receptor-positive breast cancer by Martin Rotbauer, Melanie Dawe, Kevin C. J. Nixon, Julissa Tsao, Tanja Durbic, Monika Sharma, Sheng-Ben Liang, Jie Zhang, Nakita E. K. Gopal, Miralem Mrkonjic, Najd Alshamlan, Adnan Karavelic, Ciara Murray, David W. Cescon, Philippe L. Bedard, Susan J. Done (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12800032.txt.
Description
Martin Rotbauer and co-authors study genes from circulating tumor cells in breast cancer in work from 2025. The cancer type is driven by estrogen and often returns late, which makes treatment choices after surgery hard.
The team built models from gene activity and gene copy data in 194 early-stage patients, using a standard risk score as the target. The activity model tracked the score strongly, and both models predicted long-term freedom from recurrence in a second dataset. Tumors with more varied copies of the signature genes had higher risk scores and grades.
Catalog record
| CREATOR | Martin Rotbauer, Melanie Dawe, Kevin C. J. Nixon, Julissa Tsao, Tanja Durbic, Monika Sharma, Sheng-Ben Liang, Jie Zhang, Nakita E. K. Gopal, Miralem Mrkonjic, Najd Alshamlan, Adnan Karavelic, Ciara Murray, David W. Cescon, Philippe L. Bedard, Susan J. Done |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |