Podocytes as novel sources of neutrophil serine proteases: expression and regulation by inflammatory molecular patterns
Aleksandra Wróblewska-Schmude, Irena Audzeyenka, Wiktoria Mallek, Magdalena Wysocka, Adam Lesner, Magdalena Narajczyk, Felicja Gajdowska, Danuta Gutowska-Owsiak, Tomasz Kulesza, Dorota Rogacka, Agnieszka Piwkowska · 2025
Read Podocytes as novel sources of neutrophil serine proteases: expression and regulation by inflammatory molecular patterns by Aleksandra Wróblewska-Schmude, Irena Audzeyenka, Wiktoria Mallek, Magdalena Wysocka, Adam Lesner, Magdalena Narajczyk, Felicja Gajdowska, Danuta Gutowska-Owsiak, Tomasz Kulesza, Dorota Rogacka, Agnieszka Piwkowska (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12799871.txt.
Description
Aleksandra Wróblewska-Schmude and colleagues report a 2025 cell study that turns up a surprise in the kidney. Podocytes, the cells that wrap the kidney's tiny filters, were long seen as a passive wall. The team shows these cells also make a set of cutting enzymes usually linked to white blood cells that fight infection.
In human and rat podocytes, the enzymes were present and active, along with the proteins that keep them in check. Signals tied to germs or cell damage changed how much the cells made and released. The cells also shed tiny packets holding the enzymes and bits of their own DNA, yet stayed alive. A further enzyme, myeloperoxidase, appeared and shifted place when the cells were stirred. The findings hint that filter cells may play an active part in kidney swelling and immune attack.
Catalog record
| CREATOR | Aleksandra Wróblewska-Schmude, Irena Audzeyenka, Wiktoria Mallek, Magdalena Wysocka, Adam Lesner, Magdalena Narajczyk, Felicja Gajdowska, Danuta Gutowska-Owsiak, Tomasz Kulesza, Dorota Rogacka, Agnieszka Piwkowska |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |