DDRGK1 preserves intervertebral disc development through ufmylation
Mingkuan Lu, Tangjun Zhou, Xiao Yang, Kexin Liu, Kewei Rong, Peixiang Ma, An Qin, Jie Zhao · 2025
Read DDRGK1 preserves intervertebral disc development through ufmylation by Mingkuan Lu, Tangjun Zhou, Xiao Yang, Kexin Liu, Kewei Rong, Peixiang Ma, An Qin, Jie Zhao (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12799856.txt.
Description
Mingkuan Lu and co-authors delete a tagging-system gene in mouse cartilage and watch spinal discs fail to build and keep their shape. Their 2025 study targets DDRGK1, a part of the ufmylation machinery that tags proteins. That system's role in disc growth was unknown.
Mice lacking the gene in cartilage showed stunted spines and messy discs from early life. Later deletion thinned the disc's endplates and sped decay. After a spine-destabilizing surgery, gene-free mice decayed worse than normal ones. Gene reads from their disc cells lit up death, matrix-chewing, and protein-folding stress paths. Stains confirmed more cell death and more stress in both disc zones. The authors credit the gene with guarding disc cell fate.
Catalog record
| CREATOR | Mingkuan Lu, Tangjun Zhou, Xiao Yang, Kexin Liu, Kewei Rong, Peixiang Ma, An Qin, Jie Zhao |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |