PRMT3-mediated FOXO1 arginine methylation exacerbates oxidative stress-induced decidualization defects in the eutopic endometrium of endometriosis
Fangyuan Sun, Yiting Chen, Yuanyuan Li, Shucai Zhang, Ting Yu, Mingyan Jiang, Aifang Jiang, Chune Ren, Xiaoyan Zhong, Jae-Wook Jeong, Tingting Yang · 2025
Read PRMT3-mediated FOXO1 arginine methylation exacerbates oxidative stress-induced decidualization defects in the eutopic endometrium of endometriosis by Fangyuan Sun, Yiting Chen, Yuanyuan Li, Shucai Zhang, Ting Yu, Mingyan Jiang, Aifang Jiang, Chune Ren, Xiaoyan Zhong, Jae-Wook Jeong, Tingting Yang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12799844.txt.
Description
Eleven researchers trace a cause of poor womb lining preparation in endometriosis, a condition in which tissue like the womb lining grows outside the womb and often brings infertility. The team focuses on PRMT3, an enzyme that adds methyl tags to proteins. They report that the enzyme harms decidualization, the monthly change that readies the lining for an embryo.
The enzyme tags the protein FOXO1 at one arginine site, which speeds its breakdown and keeps it out of the cell nucleus. That tagging also raises oxidative stress, which further blocks the lining from maturing. In animal tests, a drug that blocks the enzyme reduced disease growth, improved the lining response, and supported embryo growth. The authors propose the enzyme as a promising drug target for endometriosis and its related infertility.
Catalog record
| CREATOR | Fangyuan Sun, Yiting Chen, Yuanyuan Li, Shucai Zhang, Ting Yu, Mingyan Jiang, Aifang Jiang, Chune Ren, Xiaoyan Zhong, Jae-Wook Jeong, Tingting Yang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |