Long-term clinical control in acromegaly patients with postoperative discordant nadir growth hormone during oral glucose tolerance test and insulin-like growth factor 1 levels: a retrospective observational study and literature review
Tomohisa Ishida, Tomohiro Kawaguchi, Yoshikazu Ogawa, Hidenori Endo · 2025
Read Long-term clinical control in acromegaly patients with postoperative discordant nadir growth hormone during oral glucose tolerance test and insulin-like growth factor 1 levels: a retrospective observational study and literature review by Tomohisa Ishida, Tomohiro Kawaguchi, Yoshikazu Ogawa, Hidenori Endo (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12799651.txt.
Description
Tomohisa Ishida, Tomohiro Kawaguchi, Yoshikazu Ogawa, and Hidenori Endo follow patients whose two hormone tests disagree after surgery for acromegaly. The disease comes from a pituitary tumor that makes too much growth hormone. After surgery, doctors check a growth factor called IGF-1 and a glucose test that should suppress growth hormone. When the two tests point opposite ways, the best course is unclear.
The team reviewed 52 patients tracked for over a year after surgery at one hospital, and ten showed the mismatch. In three, IGF-1 was high while suppression looked normal, and IGF-1 settled down on its own within three to five years. In seven, suppression stayed abnormal while IGF-1 stayed normal, and signs stayed stable for up to eleven years. The authors advise watchful waiting when IGF-1 is normal, published in 2025.
Catalog record
| CREATOR | Tomohisa Ishida, Tomohiro Kawaguchi, Yoshikazu Ogawa, Hidenori Endo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |