In vitro and in vivo studies on the activity and selectivity of butoconazole in experimental infection by Trypanosoma cruzi
Gabriela Rodrigues Leite, Denise da Gama Jaen Batista, Marcos Meuser Batista, Krislayne Nunes da Costa, Tomás Mac Loughlin, Emilia M Barrionuevo, Alan Talevi, Lucas N Aberca, Otacilio C Moreira, Amanda Faier-Pereira, Beatriz Iandra da Silva Ferreira, Maria de Nazaré Correia Soeiro, Maria de Nazaré C · 2026
Read In vitro and in vivo studies on the activity and selectivity of butoconazole in experimental infection by Trypanosoma cruzi by Gabriela Rodrigues Leite, Denise da Gama Jaen Batista, Marcos Meuser Batista, Krislayne Nunes da Costa, Tomás Mac Loughlin, Emilia M Barrionuevo, Alan Talevi, Lucas N Aberca, Otacilio C Moreira, Amanda Faier-Pereira, Beatriz Iandra da Silva Ferreira, Maria de Nazaré Correia Soeiro, Maria de Nazaré C (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12799219.txt.
Description
Gabriela Rodrigues Leite and co-authors test a repurposed drug against the parasite that causes Chagas disease in a study published in 2025. Only two drugs treat this infection, and both work poorly in its later stage. A computer screen of known chemicals flagged butoconazole, a drug from another field, as a promising hit worth testing in the lab.
In dish tests, the drug killed the parasite's hidden form at very low doses, far more strongly than the standard drug benznidazole. It also cleared parasites from washed cells, and pairing the two drugs gave an added effect. In infected mice, the new drug alone could not suppress parasites in the blood but kept animals alive. The pair cut blood parasites and raised survival, yet sensitive tests still found parasite DNA in every heart, so no cure was achieved.
Catalog record
| CREATOR | Gabriela Rodrigues Leite, Denise da Gama Jaen Batista, Marcos Meuser Batista, Krislayne Nunes da Costa, Tomás Mac Loughlin, Emilia M Barrionuevo, Alan Talevi, Lucas N Aberca, Otacilio C Moreira, Amanda Faier-Pereira, Beatriz Iandra da Silva Ferreira, Maria de Nazaré Correia Soeiro, Maria de Nazaré C |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |