Antiproliferative and apoptotic activity of a Zn(II) complex against cancer cells, both in vitro and in vivo
Kazi Soha, K M Rashel, Arifur Rahman, Tasnima Kamal, Tumpa Rani Majumder, Saswata Rabi, Pradip Paul, M Matakabbir Hossain, Abdul Auwal, Tasfik Ul Haque Pronoy, Syed Rashel Kabir, M Habibur Rahman, Tapashi G Roy, Nitai Roy, Jahan Ara Khanam, Farhadul Islam · 2025
Read Antiproliferative and apoptotic activity of a Zn(II) complex against cancer cells, both in vitro and in vivo by Kazi Soha, K M Rashel, Arifur Rahman, Tasnima Kamal, Tumpa Rani Majumder, Saswata Rabi, Pradip Paul, M Matakabbir Hossain, Abdul Auwal, Tasfik Ul Haque Pronoy, Syed Rashel Kabir, M Habibur Rahman, Tapashi G Roy, Nitai Roy, Jahan Ara Khanam, Farhadul Islam (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12796024.txt.
Description
Kazi Soha and fifteen co-authors published a cancer pharmacology study in twenty twenty-five on a zinc complex built as a gentler chemotherapy candidate. Standard chemotherapy is limited by resistance and side effects, so metal-based alternatives are under active study. The team synthesized a zinc compound carrying thiocyanate groups and tested it thoroughly.
Against breast cancer cells in dishes, it blocked growth in a dose-dependent way and pushed cells into programmed death, switching on genes like p53 and Bax. In mice carrying tumor cells, it reduced tumor burden and extended survival. Blood and tissue checks assessed harm to the host. The authors present the compound as effective in both settings with manageable toxicity.
Catalog record
| CREATOR | Kazi Soha, K M Rashel, Arifur Rahman, Tasnima Kamal, Tumpa Rani Majumder, Saswata Rabi, Pradip Paul, M Matakabbir Hossain, Abdul Auwal, Tasfik Ul Haque Pronoy, Syed Rashel Kabir, M Habibur Rahman, Tapashi G Roy, Nitai Roy, Jahan Ara Khanam, Farhadul Islam |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |