Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance
Qingjuan Zhu, Sien Van de Velde, Stefanie Wijnants, Hans Carolus, Stef Jacobs, Dimitrios Sofras, Paul Vandecruys, Odessa Van Goethem, Regina Feil, Rudy Vergauwen, Wouter Van Genechten, Wim Van den Ende, Jeffrey M Rybak, Uwe Himmelreich, John E Lunn, Patrick Van Dijck · 2025
Read Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance by Qingjuan Zhu, Sien Van de Velde, Stefanie Wijnants, Hans Carolus, Stef Jacobs, Dimitrios Sofras, Paul Vandecruys, Odessa Van Goethem, Regina Feil, Rudy Vergauwen, Wouter Van Genechten, Wim Van den Ende, Jeffrey M Rybak, Uwe Himmelreich, John E Lunn, Patrick Van Dijck (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12789422.txt.
Description
Candidozyma auris is a drug-resistant fungus that causes deadly infections and is hard to treat. The authors study enzymes in the yeast's trehalose pathway and ask whether they control how well the fungus resists echinocandin drugs, the first-line treatment. Deleting the TPS2 gene made the yeast far more sensitive to these drugs, while deleting TPS1 left resistance much like the normal strain.
The sensitive strain built up a sugar phosphate called trehalose 6-phosphate, which blocked a key enzyme and cut the supply of material for chitin, a cell wall part. When the drug attacked the wall, the mutant could not patch it with extra chitin. In infected mice, the mutant also left lower fungal loads after treatment. The team names Tps2 as a possible drug target that could make current drugs work better.
Catalog record
| CREATOR | Qingjuan Zhu, Sien Van de Velde, Stefanie Wijnants, Hans Carolus, Stef Jacobs, Dimitrios Sofras, Paul Vandecruys, Odessa Van Goethem, Regina Feil, Rudy Vergauwen, Wouter Van Genechten, Wim Van den Ende, Jeffrey M Rybak, Uwe Himmelreich, John E Lunn, Patrick Van Dijck |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |