Host Protein Kinase C⍺: The novel Mitogen Activated Protein Kinase (MAPK) specific scaffold regulating nuclear export of influenza virus ribonucleoprotein complexes
Indrani Das Jana, Soumik Dey, Manoj Si, Arunava Roy, Arindam Mondal, Luis Martínez-Sobrido, Luis Martínez-Sobrido, Luis Martínez-Sobrido, Luis Martínez-Sobrido, Luis Martínez-Sobrido · 2025
Read Host Protein Kinase C⍺: The novel Mitogen Activated Protein Kinase (MAPK) specific scaffold regulating nuclear export of influenza virus ribonucleoprotein complexes by Indrani Das Jana, Soumik Dey, Manoj Si, Arunava Roy, Arindam Mondal, Luis Martínez-Sobrido, Luis Martínez-Sobrido, Luis Martínez-Sobrido, Luis Martínez-Sobrido, Luis Martínez-Sobrido (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12788653.txt.
Description
Indrani Das Jana and co-authors published this virology study in 2025 on how influenza gets its genome out of the cell nucleus. The virus copies itself in the nucleus, and its genome segments must be exported before new viruses can assemble. A host protein called PKC alpha was known to switch on a signaling chain that aids this export, but the details were missing.
The team shows the protein acts as a scaffold, physically holding the chain's parts together. It binds the upstream switch MEK1, the effector ERK2, and the viral nucleoprotein, forming one complex. ERK2 then marks the nucleoprotein at specific sites, and those marks are required for export and for the virus to spread. A broken version of the scaffold blocked the complex and cut virus production. The authors frame the protein as a key organizer the virus depends on.
Catalog record
| CREATOR | Indrani Das Jana, Soumik Dey, Manoj Si, Arunava Roy, Arindam Mondal, Luis Martínez-Sobrido, Luis Martínez-Sobrido, Luis Martínez-Sobrido, Luis Martínez-Sobrido, Luis Martínez-Sobrido |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 131 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |