Comparative Evaluation of Serum Homocysteine in Patients with Oral Submucous Fibrosis and Healthy Controls
Shilpa Shastri, Santosh Kumar, Thousif Ahmed, Singamsetty S. Madhavi, Aaron Karthik, Awaiz Ahmed · 2025
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Description
Shilpa Shastri and five co-authors published a 2025 case-control study of homocysteine levels in oral submucous fibrosis, a mouth condition tied to areca nut use that can turn malignant. The team compared 30 patients with 30 matched healthy controls, grading disease clinically and under the microscope. Blood homocysteine ran much higher in patients, averaging about 37 against 22.6 in controls.
Levels climbed further with worse clinical stage and worse tissue grade. The authors propose homocysteine as a cheap, low-burden marker for tracking the disease and flagging progression risk. The study is small and single-center, so the marker's value needs wider testing. Still, a simple blood value that rises with severity would aid clinics that see this condition often.
Catalog record
| CREATOR | Shilpa Shastri, Santosh Kumar, Thousif Ahmed, Singamsetty S. Madhavi, Aaron Karthik, Awaiz Ahmed |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 9 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |